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Yet the AAOS does acknowledge that some patients may still find benefit from the injections in certain cases. In fact, due to this, the American Academy of Orthopedic Surgeons (AAOS) recommends against the routine use of hyaluronic acid injections for osteoarthritis in its 2021 practice guidelines. This means that while the scores may differ from a mathematical standpoint, the pain levels aren’t meaningfully different in real life. In particular, many argue that while many studies may find “statistical significance” in pain scores, they actually do not have clinically significant results. Yet clinical significance is still hotly debated amongst experts.

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In fact, the European Experts on Osteoarthritis group recommends it as a treatment for mild-to-moderate osteoarthritis pain.Ī 2019 randomized trial found that hyaluronic acid injections may help alleviate mild-to-moderate osteoarthritis pain. However, some experts argue that hyaluronic acid injections have been effective in their clinical practice. A 2019 research review had similar findings. Other research from 2018 on hip osteoarthritis also found that hyaluronic acid injections had no significant improvements in pain scores compared with a placebo. In fact, the American College of Rheumatology and Arthritis Foundation guidelines from 2019 recommend against hyaluronic acid injections for the treatment of osteoarthritis, due to insufficient evidence of their effectiveness.Ī 2022 analysis of 24 studies with a total of 8,997 participants found that hyaluronic acid injections had no clinically meaningful improvements in knee osteoarthritis pain compared with a placebo. This is because many studies have found little benefit to their use.

Hyaluronic acid injections are highly controversial in the medical and research community. Are hyaluronic acid injections an effective treatment?

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